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Amniotic epithelial cells : ウィキペディア英語版
Amniotic epithelial cells
Amniotic epithelial cells are a form of stem cells extracted from the lining of the inner membrane of the placenta. Amniotic epithelial cells start to develop around 8 days post fertilization. These cells are known to have some of the same markers as embryonic stem cells, more specifically, Oct-4 and nanog. These transcription factors are the basis of the pluripotency of stem cells. Amniotic epithelial cells have the ability to develop into any of the three germ layers: endoderm, mesoderm, and ectoderm. They can develop into several organ tissues specific to these germ layers including heart, brain, and liver. The pluripotentency of the human amniotic epithelial cells makes them useful in treating and fighting diseases and disorders of the nervous system as well as other tissues of the human body. Artificial heart valves and working tracheas, as well as muscle, fat, bone, heart, neural and liver cells have all been engineered using amniotic stem cells. Tissues obtained from amniotic cell lines show promise for patients suffering from congenital diseases or malformations of the heart, liver, lungs, kidneys, and cerebral tissue.
== Transplantation Success of Amniotic Epithelial Cells ==

Amniotic epithelial cells have shown to be safe and successfully transplanted into hosts that are not related to the donor. One possible reason for this is that amniotic epithelial cells have low antigen levels that inhibit compatibility from a donor to the recipient. This makes the possibility of rejection of the cells by the recipient tissue less likely. Unlike traditional tissue transplants, where the donor and recipient have to be in complete sync as far as blood type and overall compatibility and even still can show tissue rejection, amniotic epithelial cells can be used and show a higher likelihood of tissue acceptance. Also, amniotic epithelial cells are known to promote natural wound healing as well as the inhibition of angiogenesis, which is the basic conversion of a tumor into malignant cancer.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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